Association of Cytotoxic T-Lymphocyte Antigen 4 (CTLA4) and Thyroglobulin (TG) Genetic Variants with Autoimmune Hypothyroidism
Fig 1
Relative gene expression of flCTLA4 and sCTLA4 in controls and autoimmune hypothyroidism patients: (A) Expression of flCTLA4 and sCTLA4 mRNA in 45 autoimmune hypothyroidism patients and 60 controls as suggested by Mean ΔCp. Autoimmune hypothyroidism patients showed significantly reduced mRNA levels of flCTLA4 (p<0.0001) and sCTLA4 (p = 0.001) as compared to controls. (B) Expression fold change of flCTLA4 and sCTLA4 in 45 autoimmune hypothyroidism patients and 60 controls showed approximately 0.166 and 0.342 fold decrease as determined by 2-ΔΔCp method respectively.