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Gene Regulatory Network Inference of Immunoresponsive Gene 1 (IRG1) Identifies Interferon Regulatory Factor 1 (IRF1) as Its Transcriptional Regulator in Mammalian Macrophages

Fig 4

Heatmap of transcription factors and Venn diagrams of microarrays data.

(A, B) Heatmaps of all the differentially expressed transcription factors (source: Animal TFDB) from (A) human and (B) mouse microarrays data. (C, D) Venn diagrams showing the number of differentially expressed genes and transcription factors under LPS stimulation in (C) human PBMCs-derived macrophages and (D) mouse RAW264.7 macrophages.

Fig 4

doi: https://doi.org/10.1371/journal.pone.0149050.g004