The Succinate Receptor GPR91 Is Involved in Pressure Overload-Induced Ventricular Hypertrophy
Fig 7
GPR91-PI3K/Akt signaling also exists in the human heart.
A: Representative images of echocardiographic data from control, hypertrophic and non-hypertrophic patients. B: Representative images of HE-stained RA sections from control, hypertrophic and non-hypertrophic patients. C: GPR91 expression as determined by western blot analysis of the RA of control, hypertrophic and non-hypertrophic patients. D: p-Akt/Akt expression as determined by western blot analysis of the RA of control, hypertrophic and non-hypertrophic patients. E: Bar graph showing GPR91 expression as determined by western blot analysis of the RA of control, hypertrophic and non-hypertrophic patients (n = 3). F: Bar graph p-Akt/Akt expression as determined by western blot analysis of the RA of control, hypertrophic and non-hypertrophic patients (n = 3); *P<0.05 compared to the control subjects; #P<0.05 compared to the non-hypertrophic patients.