Identification and Functional Analysis of the Mycophenolic Acid Gene Cluster of Penicillium roqueforti
Fig 5
Sensitivity towards MPA of transformant T6, with attenuated expression of mpaF, and wild-type P. roqueforti.
Ten-fold serial dilutions (106 to 10) of spores from T6 and the wild-type strain (WT) were spotted on CYA plates with (+MPA) or without (-MPA) 100 μg MPA/ml. Please note the reduction in the germination of spores of transformant T6 in presence of MPA, especially evident at dilutions 104 and 103, compared with the wild-type strain.