Two Chitotriose-Specific Lectins Show Anti-Angiogenesis, Induces Caspase-9-Mediated Apoptosis and Early Arrest of Pancreatic Tumor Cell Cycle
Fig 8
Proposed model for mechanism of apoptosis induced by BhL and DiL9 in PANC-1 cells.
Lectins bind to the glycoprotein receptors of PANC-1 cells and triggers mitochondrial membrane depolarization cascade. The apoptotic signal was amplified by activation of caspase-9 and -3 leading to final cell death.