Drug-Gene Interactions of Antihypertensive Medications and Risk of Incident Cardiovascular Disease: A Pharmacogenomics Study from the CHARGE Consortium
Fig 1
Plots show the individual interaction p-values based on Stage I (indicated as solid dots) or Stage I + Stage II meta-analysis (indicated as outlined dots with “+” symbol) against their genomic position for the combined cardiovascular disease (CVD) outcome for the four antihypertensive medication exposures: (a) Angiotensin-converting enzyme (ACE) inhibitors, (b) Beta-blockers, (c) Calcium Channel Blockers, and (d) Thiazide Diuretics.
Within each chromosome, shown on the x-axis, the results are plotted left to right from the p-terminal end. The nearest genes are indicated for variants with an interaction p-value less than 1×10−5 in the meta-analysis.