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Naturally Occurring Deletion Mutants of the Pig-Specific, Intestinal Crypt Epithelial Cell Protein CLCA4b without Apparent Phenotype

Fig 6

The porcine CLCA proteins CLCA1, CLCA4a and CLCA4b occupy different cellular niches in the intestinal tract.

The CLCA4a protein (blue) had previously been detected exclusively in small intestinal villus enterocytes. In contrast, its paralog CLCA4b (orange) is expressed only in small and large intestinal crypt epithelial cells where the porcine CFTR protein (green) is also expressed. Moreover, a third CLCA protein, the fully secreted CLCA1 (brown) is expressed by goblet cells. Thus, each porcine CLCA protein appears to occupy a distinct functional niche in small and large intestine. Interestingly, the combination of CLCA4a (blue) and CLCA4b (orange) represent the expression pattern of their single murine ortholog CLCA4a (compare Bothe et al. 2008). G = goblet cell, NG = non-goblet enterocyte.

Fig 6

doi: https://doi.org/10.1371/journal.pone.0140050.g006