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Annexin A2 Acts as an Adhesion Molecule on the Endometrial Epithelium during Implantation in Mice

Fig 2

Expression of Axna2 at implantation sites.

On Day 4 of pregnancy, the immunoreactivities (brown) at the implantation sites were weak at 10:00 am (A). The signal increased at 4:00 pm (B). At 4:00 pm, the signal was strong at the implantation sites (B) and in the nearby stroma (Str) (C). Concentration of signal was observed at the interface between the luminal epithelium (LE) and the embryo (emb) (D, E) but not between LE (F). Immunofluorescence staining showed that Axna2 immunoreactivies (green) were on the membrane of the endometrial stroma on Day 4 (G) and Day 5 (H) of pregnancy. The immunoreactivies became cytosolic on Day 6 of pregnancy (I).

Fig 2

doi: https://doi.org/10.1371/journal.pone.0139506.g002