Mitochondrial ROS Induces Cardiac Inflammation via a Pathway through mtDNA Damage in a Pneumonia-Related Sepsis Model
Fig 8
Mito-Vit-E attenuates myocardial damage after sepsis.
Rats were infected by S. pneumoniae or given PBS sham control. 21.5 μmoles/kg Mito-Vit-E (MVE) or vehicle was administered orally 30 minutes post-inoculation, and heart tissues were harvested 24 hours later. A. Serum levels of troponin I (cTnI) were measured by ELISA assay. All values are means ±SE. Significant differences are shown as * between sham and sepsis and Δ between vehicle and Mito-Vit-E (p<0.05, n = 6). In addition, heart tissue sections were applied to H&E staining (B) and TUNEL assay (green) (C). In C, cell nucleuses were identified by propidium iodide (PI) staining (Red). The original magnification is 40 fold, and images are representative of a random selection of at least 3 sections of N = 6.