Skeletal Muscle an Active Compartment in the Sequestering and Metabolism of Doxorubicin Chemotherapy
Fig 1
Doxorubicin (A) and Doxorubicinol (B) concentrations in the arterial plasma following the IP administration of 1.5 or 4.5 mg kg-1 Doxorubicin.
(A) Significance compared to baseline for the 1.5 mg kg-1 dose is denoted by ✝ and 4.5 mg kg-1 by *. α Denotes an increase (P<0.05) compared to 24, 48, 72, 120, 144 and 168 hours as a result of the 1.5 mg kg-1 dose. β Denotes difference (P<0.05) between administered doses. (B) Significance compared to baseline for the 1.5 mg kg-1 dose is denoted by ✝ and 4.5 mg kg-1 by *. α Denotes a decrease (P<0.05) compared to 24 hours. β Denotes difference (P<0.05) between administered doses.