Vasomotor Reaction to Cyclooxygenase-1-Mediated Prostacyclin Synthesis in Carotid Arteries from Two-Kidney-One-Clip Hypertensive Mice
Fig 6
Effect of COX-1-/- on the response to COX substrate AA and/or that evoked by ACh in NOS-inhibited HTN carotid arteries.
A: representative traces showing that contraction evoked by AA in HTN (top) or that in COX-1-/- 2K1C hypertensive vessels (HTN/KO; bottom) arteries. B: summary of the response evoked by ACh (10 μM) and that to AA (10 μM) in HTN/KO as compared to HTN counterparts. C: representative traces showing responses evoked by ACh (10 μM) in HTN (top) and HTN/KO arteries (bottom) pre-contracted with PE (2 μM). D: Summarized results of C together with that obtained with non-selective COX inhibitor indomethacin (10 μM) in WT hypertensive vessels (HTN+IND). In A & C, values were expressed as mean ± SEM (n = 5 for each). **P<0.01 as compared to HTN. NS: not significant.