Self-Assembly of Aβ40, Aβ42 and Aβ43 Peptides in Aqueous Mixtures of Fluorinated Alcohols
Fig 9
CD spectra recorded for Aβ40 (∙∙∙∙∙∙∙∙), Aβ42 (——-), and Aβ43 (—).
From freshly dissolved HFIP stocks at 20 μM peptide concentrations (Panel A), from deionized water stocks incubated for 72 hours at 100 μM peptide concentrations at 37°C, after diluting to 20 μM peptide concentrations (Panel B), and from freshly prepared solutions of 2% HFIP in PB (Panel C) at 20, 10, and 5 μM concentrations for Aβ40, Aβ42, and Aβ43, respectively. From freshly prepared solutions in 10% HFIP (Panel D), 20% HFIP (Panel E) and 50% HFIP (Panel F) in PB at 20, 10 and 5 μM concentrations for Aβ40, Aβ42, and Aβ43, respectively. From freshly prepared solutions in 10% HFIP (Panel G), 20% HFIP (Panel H) and 50% HFIP (Panel I) in deionized water at 20, 10, and 5 μM concentrations for Aβ40, Aβ42, and Aβ43, respectively.