Impact of AMP-Activated Protein Kinase α1 Deficiency on Tissue Injury following Unilateral Ureteral Obstruction
Fig 5
Ampkα1 sensitive up-regulation of Tak1 target genes following unilateral ureteral obstruction.
Arithmetic means ± SEM (n = 9) of c-Fos (A), interleukin 6 (Il6, B), Pai1 (C) and Snai1 (D) relative mRNA expression in renal tissue from non-obstructed control kidney (CTR) and obstructed kidney (UUO) of Ampkα1 knockout mice (black bars) and respective wild-type mice (white bars) following 7 days of unilateral ureteral obstruction. *(p<0.05), ***(p<0.001) statistically significant vs control kidney tissues of respective mice; #(p<0.05), ##(p<0.01) statistically significant vs. respective kidney tissues of wild-type mice.