2-Benzazolyl-4-Piperazin-1-Ylsulfonylbenzenecarbohydroxamic Acids as Novel Selective Histone Deacetylase-6 Inhibitors with Antiproliferative Activity
Fig 5
A, B: 9b and 9c strongly alter cell cycle distribution of cancer cells.
HCC4017 lung cancer cells show defects in S-phase progression and accumulation in G2/M after treatment with 9b (in A) or 9c (in B), as indicated. Cell cycle histograms were collected on PI stained samples of floating and adherent cells, on a FACs Calibur.