Human Urinary Kallidinogenase Promotes Angiogenesis and Cerebral Perfusion in Experimental Stroke
Fig 2
HUK enhanced cerebral blood perfusion and promoted angiogenesis in stroke rats.
(A) Representative images of 18F-FDG PET/CT in HUK group and vehicle group at 1 d and 14 d after stroke. (B) Uptake of 18F-FDG in HUK or vehicle-treated rats at different time points after stroke. *p<0.05 versus vehicle group; **p<0.01 versus vehicle group, N = 10 per group. (C) Left panel showed the typical detected areas of CD31 staining in rats brain indicated in boxed area. Right panel demonstrated representativeimmunofluorescent images stained by CD31 (green) 7 days after reperfusion. Scale bar = 100 μm. (D) CD31 positive vessels were counted and analyzed at indicated time point. Data was presented as capillary density reflected by number of CD31 positive vessels per mm2. #p<0.05 versus sham group; ##p<0.01 versus sham group; *p<0.05 versus vehicle group; **p<0.01 versus vehicle group. N = 6 per group. (E) Quantitative data of CD31 mRNA levels at 1, 3, 7, and 14 d after stroke onset. # p<0.05 versus sham group; *p<0.05 versus control group. N = 6 per group.