Treatment with a Small Molecule Mutant IDH1 Inhibitor Suppresses Tumorigenic Activity and Decreases Production of the Oncometabolite 2-Hydroxyglutarate in Human Chondrosarcoma Cells
Fig 3
A Patient with IDH2 Mutant Dedifferentiated Chondrosarcoma Demonstrates a Drop in D-2HG Plasma and Urine Levels after Surgical Resection.
A: Histologic image of this patient’s dedifferentiated chondrosarcoma showing neoplastic cartilage (Arrow a) juxtaposed to higher grade, and more cellular regions resembling fibrosarcomatous elements (dedifferentiated component, Arrow b.) B: plain radiograph pre- (left) and post-operation (right). Bracket delineates the tumor. C: PCR-based DNA sequencing showed that this patient’s tumor exhibits an IDH2 R172S (AGG>AGT) missense mutation. D: D-2HG levels measured in patient plasma samples showed a decrease after surgical resection. E: D-2HG levels measured in patient urine samples showed a decrease after surgical resection. Error bars depict one standard error of the mean (SEM) from three measurements.