HLA-B27-Homodimer-Specific Antibody Modulates the Expansion of Pro-Inflammatory T-Cells in HLA-B27 Transgenic Rats
Fig 8
Pro-inflammatory cytokines increase cell-surface B272 homodimers.
(A-E) Cell cultures of leukocyte populations were analyzed by flow cytometry for presence of cell-surface B272 homodimers after stimulation with cytokines. HD6-biotinylated and streptavidin APC were used for detection. Mean fluorescence intensity (MFI) values were plotted from data analysis. Statistical analysis was plotted against “without cytokines” data values. Values are expressed as mean±SEM. *p<0.05, **p<0.01, ***p<0.005 as determined by one-way ANOVA followed by Bonferroni post-hoc analysis.