Brown Adipose Tissue Response Dynamics: In Vivo Insights with the Voltage Sensor 18F-Fluorobenzyl Triphenyl Phosphonium
Fig 2
18F-FBnTP Uptake Kinetics and Selectivity to BAT at Rest.
18F-FBnTP PET images acquired in same animal before (A—C) and after surgical excision of BAT (D), and related time-activity curves (E—F). Note the lack of uptake in the interscapular area after BAT excision (D). Images in (A to C) and (D) represent PET scans acquired in the same animal at an interval of 12 min. Chart in (E) represents 18F-FBnTP time activity curve generated from the same animal in (A to C). Chart in (F) is zooming of the first 240 sec in (E). Y-axis in (F) has same unit value and scale as in (E). Note the strong 18F-FBnTP uptake in BAT, which is similar to that in the heart, and 8 times greater than background activity (E). 18F-FBnTP reaches plateau concentration in BAT within less than a minute (F).