Foxg1-Cre Mediated Lrp2 Inactivation in the Developing Mouse Neural Retina, Ciliary and Retinal Pigment Epithelia Models Congenital High Myopia
Fig 3
Opthalmological evaluation of control and mutant mice.
Similar gross morphology of the anterior segment in control (A, A’) and Lrp2FoxG1.cre-KO mutant littermates at P90 (B, B’). In some cases pupillary ectopia was observed in the mutants (C, C’). Fundus photographs of control (D, F) and mutant eyes (E, G) at P60 (D, E) and P180 (F, G) respectively show chorioretinal atrophy and peripapillary staphyloma. (H) Comparisons of intraocular pressure between control and mutant littermates at the indicated postnatal ages. Two-way ANOVA post hoc Tukey test was used, ***P<0.001, ns: not statistically significant, values are mean ± SEM of 10 animals per age and genotype.