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DNA Physical Properties and Nucleosome Positions Are Major Determinants of HIV-1 Integrase Selectivity

Fig 6

Autocorrelations between integration sites identified on three selected sequences (CL528939, CL529481 and CL529183).

Autocorrelations were calculated between integration sites identified on three selected sequences and corresponding to different conditions of integration. A) IN-LEDGF/p75 on DNA, B) IN-LEDGF/p75 on PN assembled at histone/DNA ratio (0.74 μg/1 μg), C) IN-LEDGF/p75 on PN assembled at histone/DNA ratio (1.3 μg/1 μg) and D) IN on PN assembled at histone/DNA ratio (1.3 μg/1 μg). For each panel, autocorrelations were calculated between integration sites of the same strand (+/+ red and-/- blue) or complementary strands (+/- green).

Fig 6

doi: https://doi.org/10.1371/journal.pone.0129427.g006