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Role of Areca Nut Induced TGF-β and Epithelial-Mesenchymal Interaction in the Pathogenesis of Oral Submucous Fibrosis

Fig 2

Areca nut induces different gene expression profiles in fibroblast and epithelial cells.

Venn diagram representation of genes regulated by areca nut in epithelial (HaCaT, GSE 38227) and fibroblast cells (hGF). 457 genes are commonly regulated by areca nut in both the cell types while bulk of the differentially regulated genes (1152 in HaCaT and 4209 in hGF) are mutually exclusive.

Fig 2

doi: https://doi.org/10.1371/journal.pone.0129252.g002