Fructose Mediated Non-Alcoholic Fatty Liver Is Attenuated by HO-1-SIRT1 Module in Murine Hepatocytes and Mice Fed a High Fructose Diet
Fig 2
Effect of CoPP with and without SIRT1-siRNA, and with and without SIRT plasmid on pAMPK, PPARα, FAS expression and triglyceride levels in fructose (Fr)-treated hepatocytes.
(A) pAMPK/AMPK expression by western blot analysis. (B) PPARα mRNA levels. (C) FAS mRNA levels measured by RT-PCR in hepatocytes. Results are mean±SE, n = 4/group. * p<0.05 vs CTR; # p<0.05 vs HFr, + p<0.05 vs HFr+CoPP, $ vs Fr+CoPP+SIRT Plasmid. (D) Triglyceride levels measured by RT-PCR in hepatocytes. Results are mean±SE, n = 4/group. * p<0.05 vs CTR; # p<0.05 vs HFr, + p<0.05 vs HFr+CoPP, $ vs Fr+CoPP+SIRT Plasmid. Fig 2A AMPK panel is excluded from this article's CC-BY license. See the accompanying retraction notice for more information.