Genome-Wide Definition of Promoter and Enhancer Usage during Neural Induction of Human Embryonic Stem Cells
Fig 5
Networks of genes associated to NESC-specific and up-regulated CAGE promoters.
The networks visually represent the connections between the genes associated to NESC-specific (up) and up-regulated CAGE promoters (down). Most of the genes are included in the regulatory pathways of axonal guidance signaling, ESC pluripotency and signal transduction. Purple arrows indicate the connections between genes based on the Ingenuity Knowledge Base dataset (dotted or solid lines for indirect and direct relationships respectively). Then, genes included in IPA canonical pathways (CP) are indicated by grey arrows. The shape of the gene symbol indicates the corresponding protein function, while the color (from white to red) represents the CAGE expression level of the promoter associated to the gene (for NESC-specific promoters) or its ratio between ESCs and NESCs (for upregulated CAGE promoters). For a complete IPA legend see http://ingenuity.force.com/ipa/articles/Feature_Description/Legend