Assembly of a Comprehensive Regulatory Network for the Mammalian Circadian Clock: A Bioinformatics Approach
Fig 3
Correlation distributions for clock network gene pairs versus random gene pairs.
The cumulative Pearson ρ distributions of pairs of ECCN genes reported to interact but excluding CCN (ECCN, green), reported pairs of CCN genes (CCN, orange), and 43 randomly chosen genes versus all genes as background (BG, black) are shown for the Hsa2 data collection (A, B). Distributions are shown centred around 0 with the centred bin marked by the dashed red line. The Pearson ρ distributions of reported pairs of ECCN genes (green) is compared to not reported pairs (blue) for the data set Hsa2 (C, D). Comparison of Pearson ρ and mutual rank (E, F) between all possible pairs of ECCN genes (green) and all possible pairs of non-ECCN genes as background (black). All data were taken from the Hsa2 data collection.