Safety of Intracoronary Infusion of 20 Million C-Kit Positive Human Cardiac Stem Cells in Pigs
Fig 5
Intracoronary infusion of 20 million human c-kitpos CSCs does not impair left ventricular (LV) function or morphology.
The line graphs in the top panel show individual values of each pig’s progress over time (baseline, 6, 12, 24 h, 1 week, and 1 month). Individual plots are in yellow, and group means are illustrated by the red line plots. A. ejection fraction (EF). B. LV end-diastolic diameter (EDD). C. LV end-diastolic volume (EDV), D. LV anterior wall fractional thickening. The bottom panel shows group mean±SEM at each time point for respective LV functional and morphologic indices. Green and red bars indicate hCSC-treated and vehicle groups respectively. E. ejection fraction, F. fractional shortening, G. LV end-systolic area, H. LV end-diastolic area, I. LV end-systolic volume, J. LV end-diastolic volume, K. LV anterior wall thickness in systole, L. LV anterior wall thickness in diastole, M. LV end-systolic diameter, N. LV end-diastolic diameter, O. LV posterior wall thickness in systole, P. LV posterior wall thickness in diastole. Data are mean±SEM. There were no significant differences between groups with respect to any parameter at respective time points (P > 0.05).