Thalidomide Inhibits Alternative Activation of Macrophages In Vivo and In Vitro: A Potential Mechanism of Anti-Asthmatic Effect of Thalidomide
Fig 1
Effects of thalidomide on lung inflammation and AHR by allergen challenges.
A, Experimental protocol of the study. B, The number of inflammatory cells including eosinophils in BALF. C, H&E stain (a-d), ×100) and PAS stain (e-h), ×200) of lung histology after allergen challenge (a,e: PBS; b,f: PBS+Thalidomide; c,g: OVA; d,h: OVA+Thalidomide). * indicates p < 0.05. (D) Methacholine hyperresponsiveness was measured 24 h after the last intranasal challenge, n = 5–8 for each group, the ** indicates p < 0.01. Mch; methacholine bronchial challenge.