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Simple Amides of Oleanolic Acid as Effective Penetration Enhancers

Fig 3

Syntesis of oleanolic acid morpholide derivatives 9a–12a.

Reagents and conditions: I: Jones reagent, acetone, r.t.; II: hydroxylamine hydrochloride, sodium acetate, ethanol, reflux; III: phosphoryl chloride, pyridine, r.t.

Fig 3

doi: https://doi.org/10.1371/journal.pone.0122857.g003