Highly Effective Fibrinolysis by a Sequential Synergistic Combination of Mini-Dose tPA plus Low-Dose Mutant proUK
Fig 6
The effect of the synergistic dose combination in plasma alone:
The synergistic combination of the activators (0.2 μg/ml tPA and 6 μg/ml M5) was incubated (37°C) in plasma without a clot. No fibrinogenolysis occurred for at least 3 h, showing that the plasminogen activation seen with the synergistic combination was fibrin-dependent and no non-specific effect was detected by the synergistic combination.