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Time-Dependent Effect of Hypoxia on Tumor Progression and Liver Progenitor Cell Markers in Primary Liver Tumors

Fig 3

Cytokeratin 19.

A: Representative images of overall CK19 staining, early DMOG and PBS counterparts also show cytoplasmatic staining in hepatocytes B: quantified % of overall CK19 staining after 22 and 27 weeks C: Image of portal area at 400x magnification as used to count single cells, arrowheads point to single cells D: Average number of single cells per portal area for each group. Scale bars: 200μm, *p<0,05, **p<0,01. #p<0,05, ##p<0,01 compared to all other groups. CK19: cytokeratin 19; DMOG: dimethyloxaloylglycine

Fig 3

doi: https://doi.org/10.1371/journal.pone.0119555.g003