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Direct but No Transgenerational Effects of Decitabine and Vorinostat on Male Fertility

Fig 6

Transgenerational effects of decitabine and vorinostat treatment on reproductive organs and semen parameters.

A) Percentage of diploid cells (undifferentiated germ cells and somatic cells) and B) of “double diploid” cells (spermatocytes) in the testes, C) Bi-testes weight, D) diameter of seminiferous tubules, E) height of seminiferous epithelium, F) sperm vitality. One point represents one animal. A)—C), E) The median (± interquartile range) or D), F) the mean (± SEM) are shown, *: p < 0.05, **: p < 0.01, ***: p < 0.001, ****: p < 0.0001.

Fig 6

doi: https://doi.org/10.1371/journal.pone.0117839.g006