Plasma Soluble Prion Protein, a Potential Biomarker for Sport-Related Concussions: A Pilot Study
Fig 4
Comparison between Normal and Post-Concussion.
A) Two-tailed unpaired student’s t-test shows post-TBI PrPC concentrations (n = 6; 2.96 ng/mL ± 0.37 SEM) are significantly elevated compared with either offseason athlete baseline concentration (n = 76’ 1.59 ng/mL ± 0.07 SEM)(p< 0.0001), or both athletes and non-athletes combined (n = 103; 1.70 ng/mL ± 0.07 SEM)(p<0.0001). B) Two-tailed paired t-test shows there was no significant difference between three sets of pre- and post-TBI PrPC values (p = 0.1666).