SOX10 Transactivates S100B to Suppress Schwann Cell Proliferation and to Promote Myelination
Figure 3
Suppression of S100B and Mpz expression by SOX10 insufficiency in Schwann cells.
(A) mRNA levels of Sox10 (top), S100b (middle) and Mpz (bottom) in stable lines of primary rat Schwann cells retrovirally transfected with shRNA specific for Sox10 or GFP. All experiments were repeated independently three times with data shown as the mean ± SEM. *P<0.05 versus GFP or sh-GFP. (B) Protein levels of SOX10 and S100B in stable lines of primary rat Schwann cells retrovirally transfected with shRNA specific for SOX10 or control GFP.