IL-17/miR-192/IL-17Rs Regulatory Feedback Loop Facilitates Multiple Myeloma Progression
Figure 3
Loss of miR-192 mimicked the effects of IL-17 on MM cells.
(A) Downregulation of miR-192 in MM1S cells was induced by transfecting cells with miR-192 inhibitor. (B) Loss of miR-192 induced cell proliferation. (C) Loss of miR-192 repressed cellular apoptosis. (D) Canonical histogram of apoptotic rate characterized by Annexin-FITC positive cells was shown. (E) Loss of miR-192 decreased cell adhesion to fibronectin and collagen I. (F) Loss of miR-192 promoted cell migration. (G) Loss of miR-192 induced EMT and Rac1 expression of cells. (**P<0.01, *P<0.05, Figure is representative of 3 experiments with similar results.).