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Unprecedented Therapeutic Potential with a Combination of A2A/NR2B Receptor Antagonists as Observed in the 6-OHDA Lesioned Rat Model of Parkinson's Disease

Figure 1

Quantification of TH and NeuN in the dopaminergic system after 6-OHDA lesioning.

Intensity of TH and NeuN positive immunostaining of the substantia nigra pars compacta (left) and striatum (right) in rats (n = 24) following administration of 10 µg of 6-OHDA in the medial forebrain bundle of the right hemisphere. Immunostaining was performed in rats having received vehicle treatment only.

Figure 1

doi: https://doi.org/10.1371/journal.pone.0114086.g001