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Crushed and Injected Buprenorphine Tablets: Characteristics of Princeps and Generic Solutions

Figure 4

Scanning electron microscope images of insoluble particles of Subutex (left panel) and generic (right panel).

A and F: solution before filtration; B–E and G–J: solution after cotton-filtration. B and G image (and inlay) were analysed after gold/paladium-coating. C–E and H–J: the magnification of the scanning microscope being varied from 250 to 2500 after carbon-coating.

Figure 4

doi: https://doi.org/10.1371/journal.pone.0113991.g004