Wild Type RTA and Less Toxic Variants Have Distinct Requirements for Png1 for Their Depurination Activity and Toxicity in Saccharomyces cerevisiae
Figure 9
A model describing the involvement of Png1 in the deglycosylation of preG83D and wild type preRTA.
The preG83D is deglycosylated by the Png1 on the ER membrane and is targeted to the proteasome for degradation. Wild type preRTA is deglycosylated by the free pool of Png1 in the cytosol, preventing its degradation by the proteasome.