Tailoring Subunit Vaccine Immunity with Adjuvant Combinations and Delivery Routes Using the Middle East Respiratory Coronavirus (MERS-CoV) Receptor-Binding Domain as an Antigen
Figure 4
The neutralization antibody responses induced in the immunized mice.
Heat-inactived sera after the third vaccination were used for the detection of the neutralization antibodies by MERS-CoV pseudovirus system. Neutralization titres were calculated when the relative inhibition rate was higher than 50%. Data are presented as means with standard error of the mean (SEM). Statistical significance was defined as **p<0.01. A, alum; C, CpG; P, poly(I:C); I, IFA. Each group contained 8 mice and all experiments repeated for 3 times.