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Inhibitors of the Interferon Response Enhance Virus Replication In Vitro

Figure 3

Effect of a combination of different IFN inhibitors on BUNΔNSs growth in A549 and Vero cells.

(a) BUNΔNSs plaque formation in A549 or Vero cells in the presence of TPCA-1 or Ruxolitinib (RUX), TPCA-1 and RUX in combination with each other or PIV5-V. Each inhibitor was used at 2 µM and compared to the equivalent volume of DMSO when the inhibitors were used in combination. Plaque size formation was assessed 42 hours post infection (p.i) in A549 cells and both 42 and 72 hours p.i. in Vero cells. Plaques were visualized by crystal violet staining. (b) BUNΔNSs virus growth monitored over time in A549 cells in the presence of 4 µM RUX, the equivalent volume of DMSO or PIV5-V and Vero cells. Supernatants were reserved and pfu/ml determined by titration in Vero cells.

Figure 3

doi: https://doi.org/10.1371/journal.pone.0112014.g003