Role of Compartmentalization on HiF-1α Degradation Dynamics during Changing Oxygen Conditions: A Computational Approach
Figure 10
Effects of siRNA therapy on HiF-1α level evolution after reoxygenation.
Reoxygenation after a hypoxic event is simulated for the HiF-1α synthesis rate = 1000 (black curve) and
= 200 (red curve). The blue dotted line represents the normoxic level for a normal cell.