< Back to Article
A Conserved Rule for Pancreatic Islet Organization
Figure 3
Cell-to-cell contact ratios in mouse, pig, and human islets.
Based on the contacts between neighboring cells, ratios of 
, 
, and 
contacts (
, 
, and 
), depending on islet size, are calculated in (A) mouse, (B) pig, and (C) human islets. Islet size is represented by the total number of cells in islets, and categorized as small (<1000 cells), medium (1000–2000), and large (>2000) islets. Given fractions of 
and 
cells (
and 
), the 
, 
, and 
contact probabilities in random cell organization are theoretically 
, 
, and 
, respectively. The random organization (empty bar) is compared with the organization of native islets (black solid). Mean ± SEM. *P<0.005.
doi: https://doi.org/10.1371/journal.pone.0110384.g003