Characterization of Fibrillar Collagens and Extracellular Matrix of Glandular Benign Prostatic Hyperplasia Nodules
Figure 5
Association of patient age with Picrosirius red collagen content in prostate tissues.
The association of Picrosirius red collagen content and patient age at time of surgery was investigated in cohorts of BPH only tissues (TURP set), a combination of BPH and normal prostate tissue (TMA set [all patients]), and a subset of only normal prostate tissue (TMA set [normal only]). Total collagen content and the distribution of birefringent colors were not associated with age in the TURP set or combination TMA set (all patients) of tissues (p>0.05). Total collagen content was not associated with age in the TMA subset of normal only patients (p = 0.96), but a significant negative correlation between age and birefringent color proportions was observed for red (p = 0.009) and orange (p = 0.03) birefringence. No association was found between age and yellow (p = 0.41) or green (p = 0.15) birefringence in the normal only subset of prostate tissues.