Skip to main content
Advertisement
Browse Subject Areas
?

Click through the PLOS taxonomy to find articles in your field.

For more information about PLOS Subject Areas, click here.

< Back to Article

Releasing Dentate Nucleus Cells from Purkinje Cell Inhibition Generates Output from the Cerebrocerebellum

Figure 1

Recording sites of wrist-movement-related Purkinje cells (PCs) and dentate nucleus (DN) cells.

A: Dorsal view of the right cerebellar hemisphere of monkey W. The open star indicates the center of the recording chamber. The gray dot marks the location of the electrolytic lesion indicated by the white arrowhead in B. PF: primary fissure, IV-VI: lobules IV-VI, R: rostral, L: lateral. B: Coronal section of the cerebellum of monkey W at the level of the gray line in A. The arrow indicates a recording track. The recording chamber was set at an angle to allow access to both the wrist-related cerebellar cortex and deep cerebellar nuclei (DCN). DN: dentate nucleus, AIP: anterior interpositus nucleus, PIP: posterior interpositus nucleus, h: hilum, D: dorsal, L: lateral. C: Typical examples of unit activities of simple spikes (SS, top) and complex spikes (CS, middle) for a PC and for a DN cell (DNC, bottom). D and E: Somatotopy maps of PCs for the three animals (D) and DN cells for the two animals (E). Cells with receptive fields (RFs) in distal arm (filled circles), proximal arm (open circles), face/mouth (open triangles) and hindlimb/trunk (open diamonds) are plotted. Note that all cells with RF in distal arm (filled circles) were task-related. In some cells, RF was unclear (cross marks). In D, the gray lines in the left (Monkey M) and middle (Monkey S) panels indicate locations of the PF. In the right panel (Monkey W), the open star and the PF (black line) correspond to those in A. The intersection of the two dashed lines indicates the center of the recording chamber in each animal. In E, the medial gray dashed line indicates the presumed medial edge of DN, whereas the lateral gray dashed line indicates the presumed lateral edge of DN. The medial border corresponds to the location of the axon bundle in the hilum of DN (indicated by h in B). The lateral border was estimated due to a lack of unit activities beyond the lines (See Materials and Methods). In both the cerebellar cortex and DN, recorded cells that had RFs in the face region were located caudal to the wrist-movement related cells, while cells that had RFs in the hindlimb/trunk were located rostrally.

Figure 1

doi: https://doi.org/10.1371/journal.pone.0108774.g001