Deletion of Serum Amyloid A3 Improves High Fat High Sucrose Diet-Induced Adipose Tissue Inflammation and Hyperlipidemia in Female Mice
Figure 3
Gonadal white adipose tissue inflammatory and chemotactic gene expression is attenuated in female Saa3−/− mice.
(A–H) Total RNA from whole gonadal white adipose tissue (gWAT) was reverse transcribed into cDNA for quantitative PCR analysis. Genes including Saa3 (A–B), Saa1 (C–D), Tnf (E–F), and Ccl2 (G–H) are presented, normalized to an internal control gene (Gapdh) and presented as fold change from Saa3+/+ chow controls. n = 6–15 mice per group. *P<0.05 from chow group; #P<0.05 from Saa3+/+ controls. WT: Saa3+/+; HET: Saa3+/−; KO: Saa3−/−.