Development of Stable Vibrio cholerae O1 Hikojima Type Vaccine Strains Co–Expressing the Inaba and Ogawa Lipopolysaccharide Antigens
Figure 1
O1 Inaba V. cholerae strain JS1569 was transformed with expression plasmids carrying different mutant wbeT genes. Different mutations in the wbeT gene give different levels of expression of the Ogawa antigen as seen by different levels of staining following labelling with Ogawa–specific antibodies. The plasmids were isolated and the wbeT genes sequenced. The mutations present in the different clones are indicated.