Inference of Expanded Lrp-Like Feast/Famine Transcription Factor Targets in a Non-Model Organism Using Protein Structure-Based Prediction
Figure 1
Comparison of predicted FFRP transcription factor DNA-binding specificities with in vitro (SELEX) measurements for four FFRPs.
A) The predicted DNA-binding preferences of FFRPs FL11 from P. horikoshii (left) and LrpB from S. solfataricus (right) are highly similar to in vitro measurements of the specificities of these transcription factors. B) Euclidian distance matrix for DNA PWMs between each of the predicted and experimentally measured DNA-binding specificities. Dark boxes and low values and indicate higher similarity. C) The significance of similarities between PWMs in the context of comparison between all predicted and measured PWMs (mean reciprocal TOMTOM p-values, adjusted for multiple hypotheses with n = 16, Benjamini-Hochberg method).