FGF23 Deficiency Leads to Mixed Hearing Loss and Middle Ear Malformation in Mice
Figure 6
Auditory measurements from Fgf mutant mice.
(A) ABR and (B) DPOAE thresholds demonstrate profound hearing loss at all frequencies in Fgf mice, and moderate hearing loss at high frequencies in Fgf
mice. (C) ABR wave I amplitudes appear slightly depressed in Fgf
mice but are not statistically differentiable (except at 32 kHz where threshold differences impact magnitude
). ABR amplitudes in Fgf
mice are significantly reduced compared to the other genotypes
. (D) Threshold adjusted ABR wave I latency measurements demonstrate significant increases in latency in both Fgf
and Fgf
genotypes when compared to Fgf
littermates
. Error bars present standard error of the mean.