Peyer’s Patches and Mesenteric Lymph Nodes Cooperatively Promote Enteropathy in a Mouse Model of Food Allergy
Figure 4
Potential contribution of MLNs to the intestinal inflammatory immune response.
(A) Weight changes of MLN-ectomized EW-fed (EW, n = 7); sham-operated EW-fed (Mock, n = 4); and MLN-ectomized CN-fed (CN, n = 3) mice. *, Value is significantly (P<0.05) different between those for MLN-ectomized EW and sham-operated EW groups or those for MLN-ectomized EW and MLN-ectomized CN groups. (B) Jejunal sections obtained on day 7 (during inflammation, upper panels) or on day 28 (during tolerance, lower panels). (C) Arrows indicate MLNs or site of mesenteric lymphadenectomy in OVA23-3 mice on day 7 of the EW (Mock EW or MLN-ectomized EW) or CN (MLN-ectomized CN) diet. All data are representative of two independent experiments.