Design and Synthesis of a Cell-Permeable, Drug-Like Small Molecule Inhibitor Targeting the Polo-Box Domain of Polo-Like Kinase 1
Figure 12
Inhibition of Plk1 kinase by bg-34 (A). HeLa cells were incubated with 200 µM bg-34 or with PBS and the effect of bg-34 treatment on the cancer cells was examined. Morphology of HeLa cells after incubation for 24 h with 200 µM bg-34 (B). Apoptosis in HeLa cells; apoptosis was detected by means acridine-orange staining after treatment with bg-34 for 24 h (200× magnification) (C).