Islet Autoimmunity Identifies a Unique Pattern of Impaired Pancreatic Beta-Cell Function, Markedly Reduced Pancreatic Beta Cell Mass and Insulin Resistance in Clinically Diagnosed Type 2 Diabetes
Figure 3
Insulin and glucagon immunostaining.
Immunohistochemical staining for insulin (Panel A and C) and glucagon (Panel B and D) in two different islets from different area of the pancreas in a donor with T2DM and pattern A pancreatic pathology. The first islet (panel A and B) contains both insulin and glucagon positive cells, while the second islet (Panel C and D) contains only glucagon positive cells.