Modification of Epigenetic Patterns in Low Birth Weight Children: Importance of Hypomethylation of the ACE Gene Promoter
Figure 3
Box plot of median DNA methylation of 3 CpG sites within the ACE gene promoter among BW groups stratified by ACE I/D genotypes, displayed with the scatter plot of raw data.
(A) Box plot demonstrates median DNA methylation in 42 children stratified by DD genotype (P = 0.024; Mann–Whitney Test); (B) Box plot demonstrates median DNA methylation in 63 children stratified by ID genotype (P = 0.075; Mann–Whitney Test); (C) Box plot demonstrates median DNA methylation in 10 children stratified by II genotype (P = 1.000; Mann–Whitney Test). The inside each box represents the median, and the lower and upper edges of the boxes represents the 25th and 75th percentiles, respectively, and upper and lower lines outside the boxes represent minimum and maximum values (error bars).